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Published on: July 20, 2022
Effect of Coronavirus Disease-2019 Infection on Left Atrial Functions
Elif Ergül1, Ali Gökhan Özyildiz2, Nadir Emlek1
1Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
Insights
Patients who recovered from Coronavirus disease-2019 (COVID-19) showed impaired left atrial (LA) function. Echocardiography revealed significant differences in LA volumes and emptying fractions, indicating potential long-term cardiovascular risks.
Area of Science:
- Cardiology
- Infectious Diseases
- Medical Imaging
Background:
- Left atrial (LA) dysfunction is a significant risk factor for cardiovascular events.
- Coronavirus disease-2019 (COVID-19) is a global pandemic with known cardiovascular implications.
- The long-term effects of COVID-19 on cardiac function, particularly LA function, require further investigation.
Purpose of the Study:
- To evaluate left atrial (LA) functions in patients who have recovered from COVID-19.
- To compare LA function parameters between COVID-19 survivors and a healthy control group.
Main Methods:
- A cohort of 60 COVID-19 recovered patients and 60 healthy controls were enrolled.
- Echocardiography measurements were performed to assess cardiac function.
- Demographic and echocardiographic characteristics were compared between the two groups.
Main Results:
- COVID-19 survivors exhibited higher LA maximum volume (LAVmax) and LA pre-A volume, alongside a higher LA active emptying fraction.
- A lower LA passive emptying fraction and decreased left ventricular ejection fraction were observed in the COVID-19 group.
- Isovolumetric relaxation time was also reduced in patients recovered from COVID-19.
Conclusions:
- Left atrial (LA) functions may be impaired in individuals following recovery from COVID-19 infection.
- These findings suggest potential persistent cardiovascular sequelae after COVID-19.
- Further research is warranted to understand the clinical significance and management of post-COVID-19 LA dysfunction.
Objective:
Left atrial (LA) dysfunction is a crucial risk factor for cardiovascular events, and various pathologies may affect LA function. Coronavirus disease-2019 (COVID-19) is an ongoing global pandemic causing morbidity and mortality. In the present study, we aimed to evaluate LA functions in patients who recovered from COVID-19.
Methods:
Sixty consecutive patients recovered from COVID-19 and 60 healthy individuals as a control group were included in the study. Blood samples and echocardiography measurements were obtained from each subject. The two groups were compared in terms of demographic and echocardiographic characteristics.
Results:
In the COVİD-19 group, LA maximum volume (LAVmax) (P = 0.040), LA pre-A volume (LAVpre-A) (P = 0.014), and LA active emptying fraction (P = 0.027) were higher, while LA passive emptying fraction (P = 0.035) was lower. In addition, left ventricular ejection fraction (P = 0.006) and isovolumetric relaxation time (P = 0.008) were decreased in this group. Although LA volume index was higher in the COVID-19 group, it does not reach statistical significance.
Conclusion:
LA functions may be impaired in patients recovered from COVID-19 infection.
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