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A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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Advances in RIPK1 kinase inhibitors

Lu Chen1, Xiaoqin Zhang2, Yaqing Ou3

  • 1College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Frontiers in Pharmacology
|October 17, 2022
PubMed

Insights

Programmed necrosis, regulated by receptor interacting protein 1 (RIPK1), is implicated in various diseases. This review details RIPK1 inhibitors, crucial for developing new therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Programmed necrosis is a regulated cell death pathway.
  • Receptor interacting protein 1 (RIPK1) is a key mediator in programmed necrosis.
  • RIPK1 dysregulation is linked to diseases like stroke, Alzheimer's, and cancer.

Purpose of the Study:

  • To review the structure and biological function of RIPK1.
  • To summarize recent advancements in RIPK1 kinase inhibitors.
  • To categorize existing RIPK1 inhibitors.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of structural and functional data of RIPK1.
  • Classification of RIPK1 inhibitors based on their mechanisms of action.

Main Results:

  • RIPK1 is a critical mediator in programmed necrosis.
  • RIPK1 inhibitors are classified into four categories based on their targeting.
  • These inhibitors offer potential therapeutic avenues for various diseases.

Conclusions:

  • RIPK1 kinase inhibitors represent a promising therapeutic target.
  • Further research into RIPK1 inhibitors could lead to novel treatments.
  • Understanding RIPK1's role is vital for disease intervention.
Keywords:
RIP1 (RIPK1)inhibitornecrosisprogrammed necrosisreceptor interacting protein 1 (RIP1)

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