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Related Concept Videos

Sleep Apnea01:21

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Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
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Related Experiment Video

Updated: Aug 25, 2025

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
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Lesions causing central sleep apnea localize to one common brain network.

Taoyang Yuan1, Zhentao Zuo2,3,4, Jianguo Xu1

  • 1Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in Neuroanatomy
|October 17, 2022
PubMed
Summary

Brain injuries causing central sleep apnea (CSA) involve a shared network connecting the middle cingulate gyrus and cerebellum. This network is specific to CSA, offering insights into its neuroanatomy.

Keywords:
brain imagingcentral sleep apnea (CSA)focal brain lesionslesion network mappingneuroanatomical substrate

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Area of Science:

  • Neuroscience
  • Neurology
  • Sleep Medicine

Background:

  • Central sleep apnea (CSA) is a complex sleep disorder with varied underlying causes.
  • Understanding the neuroanatomical basis of CSA is crucial for developing targeted treatments.

Purpose of the Study:

  • To identify the specific brain regions and functional connectivity network associated with central sleep apnea (CSA).
  • To elucidate the neuroanatomical substrate of CSA using lesion network mapping.

Main Methods:

  • A literature search identified 27 brain injuries linked to CSA.
  • Lesion network mapping was employed to determine the functional brain network involved in CSA pathophysiology.
  • Statistical analyses (t-test, Liebermeister test) and an independent cohort assessment were used for validation and reproducibility.

Main Results:

  • Despite heterogeneous lesion locations, CSA-related injuries consistently connected to a network involving the middle cingulate gyrus and bilateral cerebellar posterior lobes.
  • This CSA-specific connectivity pattern was distinct from networks associated with other neurological conditions.
  • Replication in an independent cohort confirmed the identified CSA-related brain network.

Conclusions:

  • Brain injuries causing CSA are associated with a common functional network characterized by connectivity to the middle cingulate gyrus and bilateral cerebellar posterior lobes.
  • These findings provide critical insights into the neuroanatomical underpinnings of central sleep apnea.