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Synthesis and crystal structure of topiramate azido-sulfate at 90 K and 298 K
Prabhakar Priyanka1, Bidarur K Jayanna1, Haruvegowda Kiran Kumar2
1Department of Chemistry, B. N. M. Institute of Technology, Bengaluru-560 070, India.
Abstract:
The low (90 K) and room (298 K) temperature crystal structures of topiramate azido-sulfate [systematic name 2,3:4,5-bis-O-(1-methyl-ethyl-idene)-β-d-fructo-pyran-ose azido-sulfate], C12H19N3O8S, an inter-mediate in the synthesis of the anti-convulsant drug topiramate, are described. Topiramate azido-sulfate (I) finds use as a reference impurity standard for topiramate. A modified synthesis and some spectroscopic details are also presented.
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