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Infantile Colic and the Subsequent Development of the Irritable Bowel Syndrome

Ju Hee Kim1, Seung Won Lee2, Yoowon Kwon3

  • 1Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea.

Journal of Neurogastroenterology and Motility
|October 17, 2022
PubMed

Insights

Infants diagnosed with colic have a higher risk of developing irritable bowel syndrome (IBS) later in childhood. Early understanding of infantile colic may help reduce functional gastrointestinal disorders.

Area of Science:

  • Gastroenterology
  • Pediatrics
  • Epidemiology

Background:

  • The association between infantile colic and later development of irritable bowel syndrome (IBS) is not well understood.
  • Infantile colic is a common condition affecting infants, but its long-term health implications require further investigation.

Purpose of the Study:

  • To investigate the association between infantile colic and the subsequent risk of developing IBS in childhood.
  • To evaluate the long-term risk of IBS in individuals with a history of infantile colic.

Main Methods:

  • A large cohort study involving 917,707 children born in Korea between 2007-2008.
  • Infantile colic was defined by ICD-10 codes R10.4 or R68.1 between 5 weeks and 4 months of age.
  • Irritable bowel syndrome (IBS) was defined by ICD-10 code K58.X after 4 years of age. Propensity score inverse probability of treatment weighting (IPTW) was used to analyze the risk.

Main Results:

  • The infantile colic group (359,842 children) showed a statistically significant increased risk of developing IBS in childhood (HR [95% CI], 1.12 [1.10–1.13]) compared to the control group (363,528 children).
  • Subgroup analyses confirmed the significant association across various factors including feeding status, birth weight, sex, and economic status.

Conclusions:

  • Infantile colic is a significant risk factor for developing IBS later in childhood.
  • Understanding the pathogenesis of infantile colic may lead to strategies for reducing the prevalence and severity of functional gastrointestinal disorders throughout life.
Abstract

Keywords:
ColicGastrointestinal diseasesIrritable bowel syndrome

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