Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Equilibrium and Balance01:15

Equilibrium and Balance

4.9K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
4.9K
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

418
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
418
Cholinergic Antagonists: Therapeutic Uses01:26

Cholinergic Antagonists: Therapeutic Uses

810
Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:    
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
810
Upper Respiratory Drugs: First and Second-Generation Antihistamines01:15

Upper Respiratory Drugs: First and Second-Generation Antihistamines

416
Antihistamines are a class of drugs widely used to alleviate the symptoms of allergies, such as sneezing, itching, and nasal congestion. They work by inhibiting the actions of histamine, which is released by immune cells in response to allergenic substances or tissue injuries.
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
416
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

301
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
301
Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

950
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
950

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Migrainous vertigo impairs adaptive learning as a function of uncertainty.

Frontiers in neurology·2026
Same author

Corrigendum: Unlocking insights into HIV care: An in-depth analysis of key populations from the Fast-Track Cities Quality of Care survey in eThekwini, KwaZulu-Natal, South Africa.

Southern African journal of HIV medicine·2026
Same author

Viral mimicry redirects immunosuppressed colorectal tumour landscapes towards a proinflammatory and CMS1-like regenerative state.

Communications biology·2026
Same author

Unlocking insights into HIV care: An in-depth analysis of key populations from the Fast-Track Cities Quality of Care survey in eThekwini, KwaZulu-Natal, South Africa.

Southern African journal of HIV medicine·2026
Same author

Initial pediatric experience of preserving cardiac allografts in a 10°C cooler.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same author

A formative evaluation of potential barriers and facilitators to inform effective implementation of a community-based hypertension care program in rural South Africa: The IMPACT-BP trial.

SSM - health systems·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
Same journal

Non-pharmacological interventions for anxiety and depression in Parkinson's disease.

The Cochrane database of systematic reviews·2026
Same journal

Biologic drugs for induction and maintenance of remission in Crohn's disease: a network meta-analysis.

The Cochrane database of systematic reviews·2026
Same journal

Preconception and first-trimester metformin for improving pregnancy outcomes in women with polycystic ovary syndrome.

The Cochrane database of systematic reviews·2026
See all related articles

Related Experiment Video

Updated: Aug 25, 2025

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation
06:18

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation

Published on: February 7, 2020

7.6K

Antihistamines for motion sickness.

Nadine Karrim1, Ryan Byrne2, Nombulelo Magula3

  • 1Institute of Research into Space Health and Astronaut Development, International Centre for Astronautical Development, Durban, South Africa.

The Cochrane Database of Systematic Reviews
|October 17, 2022
PubMed
Summary
This summary is machine-generated.

First-generation antihistamines likely reduce motion sickness symptoms in adults compared to placebo, but may increase sedation. Evidence for other uses and in children is uncertain.

More Related Videos

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
08:50

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants

Published on: December 14, 2014

9.4K
Long-term Sensory Conflict in Freely Behaving Mice
06:12

Long-term Sensory Conflict in Freely Behaving Mice

Published on: February 20, 2019

6.8K

Related Experiment Videos

Last Updated: Aug 25, 2025

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation
06:18

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation

Published on: February 7, 2020

7.6K
How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
08:50

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants

Published on: December 14, 2014

9.4K
Long-term Sensory Conflict in Freely Behaving Mice
06:12

Long-term Sensory Conflict in Freely Behaving Mice

Published on: February 20, 2019

6.8K

Area of Science:

  • Pharmacology
  • Clinical Trials
  • Evidence-Based Medicine

Background:

  • Motion sickness, characterized by nausea and vomiting, arises from passive motion or simulated environments.
  • Antihistamines are commonly used for motion sickness, but their efficacy remains debated due to conflicting study results.

Purpose of the Study:

  • To evaluate the effectiveness of antihistamines in preventing and treating motion sickness in both adults and children.
  • To synthesize evidence from randomized controlled trials (RCTs) on antihistamine use for motion sickness.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases for RCTs up to December 7, 2021.
  • Included studies involved susceptible adults and children experiencing motion sickness under natural or experimental conditions.
  • Primary outcomes included symptom prevention and resolution, with secondary outcomes on physiological measures and adverse effects.

Main Results:

  • First-generation antihistamines likely prevent motion sickness symptoms more effectively than placebo in natural settings (moderate-certainty evidence).
  • Antihistamines may increase the risk of sedation compared to placebo (low-certainty evidence).
  • Evidence for antihistamine efficacy in experimental settings, against scopolamine, antiemetics, or acupuncture, is of low or very low certainty.

Conclusions:

  • First-generation antihistamines probably reduce motion sickness symptoms in adults under natural conditions compared to placebo.
  • Antihistamines may cause more sedation than placebo, and data on children and treatment of existing symptoms are limited.
  • Certainty of evidence for other comparisons and outcomes is low to very low, indicating uncertainty regarding antihistamine effects.