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Association between Serum Erythrocyte Immune Function Indexes and Blue Light Treatment or the Severity of PJON
Insights
Erythrocyte immune function indexes can help diagnose pathological jaundice in children and assess blue light therapy effectiveness. These markers correlate with disease severity, aiding in treatment decisions for infant jaundice.
Area of Science:
- Pediatric Gastroenterology
- Neonatology
- Immunology
Background:
- Pathological jaundice in children presents diagnostic and therapeutic challenges.
- Understanding the role of erythrocyte immune function in jaundice is crucial.
Purpose of the Study:
- To investigate the association between serum erythrocyte immune function indexes and the effectiveness of blue light treatment in children with pathological jaundice.
- To determine the correlation between these indexes and disease severity.
Main Methods:
- 107 children with pathological jaundice and 69 with physiological jaundice were analyzed.
- Erythrocyte immune function indexes, including red blood cell immune complex rosettes (RBC-ICR) and red blood cell C3b receptor rosette (RBC-C3bR), were measured.
- Associations with blue light treatment efficacy and disease progression were assessed.
Main Results:
- AUC values for RBC-ICR and RBC-C3bR exceeded 0.8 in diagnosing pathological jaundice and assessing blue light therapy efficacy.
- RBC-ICR levels positively correlated with jaundice severity.
- RBC-C3bR and red blood cell immune affinity receptor (FEER) levels negatively correlated with jaundice severity (p < 0.05).
Conclusions:
- Erythrocyte immune function indexes are relevant to disease severity in pediatric pathological jaundice.
- These indexes hold diagnostic value for pathological jaundice and can assess blue light therapy efficacy in children.
Background:
The association between serum erythrocyte immune function indexes and blue light treatment effect and severity in child patients with pathological jaundice was testified.
Methods:
One hundred and seven children with pathological jaundice and 69 children with physiological jaundice were enrolled to analyze the association between erythrocyte immune function indexes and blue light treatment or disease progression.
Results:
The area under the ROC curve (AUC) of red blood cell immune complex rosettes (RBC-ICR) and red blood cell C3b receptor rosette (RBC-C3bR) in diagnosing pathological jaundice and assessing the efficacy of blue light therapy overweighed 0.8. Meanwhile, the RBC-ICR values of the child patients were positively correlated with the severity of the disease, and the RBC-C3bR and red blood cell immune affinity receptor (FEER) values were negatively correlated with them (p < 0.05).
Conclusions:
The erythrocyte immune function indexes of child patients with pathological jaundice were relevant to the disease severity, and was provided with diagnostic value for pathological jaundice or assessed value for the efficacy of blue light therapy.
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