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Evo-devo perspectives on cancer.

Aurora M Nedelcu1

  • 1Department of Biology, University of New Brunswick, PO Box 4400, Fredericton, New Brunswick, Canada E3B 5A3.

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|October 17, 2022
PubMed
Summary
This summary is machine-generated.

Evolutionary developmental biology (evo-devo) offers new insights into cancer. Integrating evo-devo with cancer research can improve our understanding of cancer

Keywords:
agingcancercancer suppression mechanismsdevelopmentevolutionsomatic maintenance

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Area of Science:

  • Evolutionary Developmental Biology
  • Cancer Biology
  • Genetics

Background:

  • Evolutionary and developmental biology approaches are increasingly linked to cancer research.
  • Existing frameworks often lack full integration of evolutionary and developmental perspectives in cancer.

Purpose of the Study:

  • To review cancer research through the lenses of evolutionary and developmental biology.
  • To explore the role of development in evolution and vice versa, specifically concerning cancer.
  • To propose an integrated evolutionary developmental framework for cancer.

Main Methods:

  • Literature review of current views on carcinogenesis invoking evolutionary and developmental perspectives.
  • Discussion of evolved cancer-suppression mechanisms in multicellularity.
  • Analysis of the interplay between the evolution of multicellularity, development, and cancer risk.

Main Results:

  • Carcinogenesis is increasingly viewed through evolutionary and developmental lenses.
  • Specific mechanisms evolved to suppress cancer during multicellularity.
  • The evolution of multicellularity and development may have been influenced by cancer, and vice versa.

Conclusions:

  • An integrated evo-devo framework for cancer can bridge disparate perspectives.
  • This framework may reveal novel insights for cancer prevention and treatment.
  • Understanding cancer's natural history through an evo-devo lens is crucial.