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Tertiary lymphoid tissues in kidney diseases: a perspective for the pediatric nephrologist

Takahisa Yoshikawa1, Yu Ho Lee2, Yuki Sato1

  • 1Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Pediatric Nephrology (Berlin, Germany)
|October 17, 2022
PubMed

Insights

Tertiary lymphoid tissues (TLTs) form in kidneys with chronic inflammation, especially in aged individuals and those with kidney diseases. Understanding age-dependent TLT formation offers new insights into kidney dysfunction and disease progression.

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • Chronic kidney disease (CKD) is a global health concern with long-term consequences, particularly in children.
  • Chronic inflammation is a hallmark of CKD, driving maladaptive repair and kidney dysfunction.
  • Tertiary lymphoid tissues (TLTs) are ectopic lymphoid structures found in non-lymphoid organs during chronic inflammation.

Conclusions:

  • Age-dependent TLT formation provides novel insights into kidney disease pathogenesis.
  • TLTs are clinically relevant in various human kidney diseases, affecting both adults and children.
  • Further research into kidney TLTs is warranted for understanding and managing CKD.

Keywords:
Chronic kidney diseaseIgA nephropathyImmunosenescenceKidney transplantationLupus nephritisTertiary lymphoid tissues

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