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Association of Maternal and Neonatal Birth Outcomes With Subsequent Pediatric Transplants

Gabriel Côté-Corriveau1,2, Thuy Mai Luu3, Marianne Bilodeau-Bertrand2

  • 1Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada.

Transplantation
|October 17, 2022
PubMed

Insights

Adverse birth outcomes like congenital anomalies and neonatal transfusions increase the risk of childhood organ transplants. These birth characteristics may help predict a child's need for transplantation.

Area of Science:

  • Pediatric Medicine
  • Transplant Surgery
  • Neonatal Care

Background:

  • Identifying factors associated with childhood organ and tissue transplants is crucial for early intervention.
  • Previous research has explored various risk factors, but specific birth characteristics require further investigation.

Purpose of the Study:

  • To determine the association between maternal and neonatal birth characteristics and the risk of organ or tissue transplantation in children.
  • To evaluate specific birth complications as potential predictors of pediatric transplant needs.

Main Methods:

  • A retrospective cohort study was conducted in Quebec, Canada, involving children born between 2006 and 2019.
  • Birth complications (congenital anomaly, neonatal blood transfusion, oligohydramnios) were analyzed as exposures.
  • Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for transplantation before age 14.

Main Results:

  • The study included over 1 million children, with 436 undergoing transplantation before age 14.
  • Congenital anomalies significantly increased the risk for heart/lung (HR: 10.41) and kidney transplants (HR: 13.69).
  • Neonatal blood transfusion was linked to all major organ transplants, and oligohydramnios to kidney transplants (HR: 16.84).

Conclusions:

  • Adverse birth outcomes, including congenital anomalies, neonatal blood transfusions, and maternal oligohydramnios, are associated with an elevated risk of transplantation in childhood.
  • These birth characteristics can serve as valuable predictors for identifying children at higher risk of needing organ or tissue transplants.
Abstract

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