Related Experiment Video
Updated: Aug 25, 2025

A Unified Methodological Framework for Vestibular Schwannoma Research
Published on: June 20, 2017
VEXAS Syndrome-A Review of Pathophysiology, Presentation, and Prognosis
Matthew J Koster1, Matthew J Samec, Kenneth J Warrington
1From the Division of Rheumatology, Mayo Clinic, Rochester, MN.
Abstract:
VEXAS ( V acuoles, E 1 enzyme, X -linked, A utoinflammatory, S omatic) syndrome is a newly identified disease caused by somatic mutations in the UBA1 gene resulting in refractory autoinflammatory features, frequently accompanied by cytopenias. Although the prevalence of this syndrome is yet unknown, understanding the clinical phenotype can assist clinicians in prompt recognition of cases among patients with glucocorticoid-responsive but immunosuppressive-resistant inflammatory symptoms. The pathophysiology, clinical presentation, diagnostic methods, treatment, and prognosis of VEXAS are herein reviewed.
Related Concept Videos
Esophageal Varices-II: Clinical Features and Management
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Esophageal Varices-I: Introduction
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

