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Related Concept Videos

Computed Tomography01:10

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Related Experiment Video

Updated: Aug 25, 2025

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography
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Internal calibration for opportunistic computed tomography muscle density analysis.

Ainsley C J Smith1,2,3, Justin J Tse2,3, Tadiwa H Waungana1,2,3

  • 1Biomedical Engineering Graduate Program, University of Calgary, Alberta, Canada.

Plos One
|October 17, 2022
PubMed
Summary

A new internal calibration method accurately measures muscle density from CT scans without needing a calibration phantom. This technique improves reliability and accessibility for assessing muscle health and weakness.

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Area of Science:

  • Radiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Muscle weakness impacts physical function and quality of life.
  • Computed tomography (CT) assesses muscle health via cross-sectional area and fat infiltration.
  • Measuring muscle density in clinical CT is limited by the absence of calibration phantoms.

Purpose of the Study:

  • To design and validate a CT internal calibration method for muscle density analysis.
  • To enable accurate muscle density assessment from opportunistic CT scans.

Main Methods:

  • CT scanning of bovine muscle samples under varied protocols and positions.
  • Testing internal calibration using regions of interest (air, blood, bone, muscle, adipose).
  • Comparing internal calibration results with a reference phantom.

Main Results:

  • Internal calibration using air and adipose/blood yielded <1% error compared to reference phantom.
  • High correlation (R2 > 0.99) between internal and reference phantom muscle density values.
  • Internal calibration showed significantly lower variation (0.33%) than Hounsfield units (6.52%).

Conclusions:

  • An internal calibration method for muscle density has been developed.
  • This method provides accurate and reliable muscle density measurements.
  • It eliminates the need for calibration phantoms in CT imaging.