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Psychotropic Drugs in the Discussion of Antimicrobial-Resistant Microorganisms

Lori Ellezian1, Archana Jhawar1,2, Yasuhiro Kyono1

  • 1Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA.

DNA and Cell Biology
|October 17, 2022
PubMed

Insights

Psychotropic drugs may promote antimicrobial resistance (AMR). Studies show antipsychotics like quetiapine can induce multidrug resistance in bacteria, raising concerns about their impact on AMR.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Psychotropic medications are recognized for their antimicrobial properties.
  • However, their potential role in fostering antimicrobial resistance (AMR) remains under-explored.
  • Recent findings indicate multidrug resistance acquisition in *Escherichia coli* upon exposure to the antipsychotic quetiapine.

Approach:

  • This review synthesizes existing scientific literature.
  • It investigates the defined relationship between psychotropic agents and AMR in microorganisms.
  • Focuses on studies examining psychotropic drug effects on microbial resistance.

Key Points:

  • Psychotropic drugs exhibit antimicrobial activity.
  • Limited research exists on psychotropics contributing to AMR.
  • Quetiapine exposure led to multidrug resistance in *E. coli*.

Conclusions:

  • A potential link exists between psychotropic drug use and the development of AMR.
  • Further research is warranted to understand the mechanisms and implications.
  • This highlights a critical area for future investigation in pharmacology and infectious disease.
Keywords:
antimicrobial resistanceantimicrobial stewardshipmental healthpsychotropic drug

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