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Related Experiment Videos

The rapid assessment of visual dysfunction in multiple sclerosis.

S Della Sala, G Comi, V Martinelli

    Journal of Neurology, Neurosurgery, and Psychiatry
    |July 1, 1987
    PubMed
    Summary

    A new contrast sensitivity test identified visual abnormalities in multiple sclerosis patients, proving more sensitive than visual evoked potentials (VEPs) in some cases. This quick test aids in diagnosing visual issues in suspected multiple sclerosis cases.

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    Evidence of thalamic gray matter loss in pediatric multiple sclerosis.

    Neurology·2008

    Area of Science:

    • Ophthalmology
    • Neurology
    • Clinical Neurophysiology

    Background:

    • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
    • Ophthalmological abnormalities are common in MS, impacting visual function.
    • Visual evoked potentials (VEPs) are established but may not detect all visual deficits.

    Purpose of the Study:

    • To evaluate the utility of a novel contrast sensitivity test in patients with multiple sclerosis.
    • To compare the sensitivity of contrast sensitivity testing with VEPs in MS patients.
    • To assess the role of contrast sensitivity in detecting visual dysfunction, particularly in optic neuritis.

    Main Methods:

    • A cohort of 41 patients (10 male, 31 female) with a confirmed diagnosis of multiple sclerosis underwent comprehensive ophthalmological examinations.

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  • Testing included standard visual evoked potentials (VEPs) and a newly developed contrast sensitivity test.
  • Data on patient demographics, clinical history (including optic neuritis), and test results were collected and analyzed.

    • Main Results:

    • Abnormal contrast sensitivity was detected in 73% of patients, while abnormal VEPs were found in 83%.
    • No direct association was observed between contrast sensitivity and VEP abnormalities.
    • The contrast sensitivity test identified visual abnormalities in all nine patients with a history of optic neuritis, whereas VEPs did not.

    Conclusions:

    • The novel contrast sensitivity test is a valuable supplementary tool for detecting visual abnormalities in patients with suspected multiple sclerosis.
    • This rapid (under 5 minutes) test demonstrates high sensitivity, especially in cases with a history of optic neuritis.
    • Contrast sensitivity testing offers a complementary approach to VEPs in the comprehensive ophthalmological assessment of MS patients.