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Related Experiment Videos

MRI in autonomic failure.

R T Brown, R J Polinsky, G Di Chiro

    Journal of Neurology, Neurosurgery, and Psychiatry
    |July 1, 1987
    PubMed
    Summary
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    Rigidity correlates with putaminal signal loss on MRI in multiple system atrophy, indicating degeneration. This MRI finding helps differentiate multiple system atrophy from pure autonomic failure.

    Area of Science:

    • Neurology
    • Radiology
    • Autonomic Disorders

    Background:

    • Multiple system atrophy (MSA) and pure autonomic failure (PAF) are distinct neurological disorders.
    • Both conditions can affect autonomic function.
    • Putaminal degeneration is a hallmark of MSA.

    Purpose of the Study:

    • To investigate the relationship between clinical rigidity and MRI findings in MSA.
    • To determine if MRI can differentiate MSA from PAF.

    Main Methods:

    • Rank correlation analysis was performed.
    • Magnetic resonance imaging (MRI) was used to assess putaminal signal intensity.
    • Patients with MSA and PAF were included.

    Main Results:

    Related Experiment Videos

  • A significant rank correlation was found between rigidity and putaminal signal dropout in MSA patients.
  • Putaminal signal dropout on MRI is associated with rigidity in MSA.
  • No putaminal abnormalities were observed on MRI in patients with PAF.

    • Conclusions:

    • Putaminal degeneration in MSA may lead to signal dropout on MRI.
    • MRI assessment of the putamen can aid in differentiating MSA from PAF.