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Published on: April 23, 2021
Cerebral microbleeds in dementia with Lewy bodies
Kai Sin Chin1, Zina Hijazi2, Leonid Churilov3
1Department of Medicine - the Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Department of Aged Care, The Royal Melbourne Hospital, Parkville, Australia; Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
Introduction:
Cerebral microbleeds (CMB) are associated with cognitive impairment and hypertensive or cerebral amyloid angiopathy. The pathophysiology and clinical significance of CMB in dementia with Lewy bodies (DLB) are not well understood. Our study aimed to investigate the prevalence of CMB in DLB and to estimate the magnitudes of their clinical associations.
Methods:
Twenty participants with DLB (mean age 74 ± 5 years) were included in this cross-sectional study. All participants underwent 3 T magnetic resonance imaging. CMB number and location were assessed on susceptibility-weighted imaging or quantitative susceptibility mapping. Amyloid-beta (Aβ) positron emission tomography (PET) scans were also performed. Between-group comparisons were estimated using risk ratios (RR) for categorical variables, and mean differences or median regression coefficients for continuous variables.
Results:
CMB were present in 30% of the DLB participants, with a lobar predominance observed. DLB with CMB were more likely to be on antithrombotic therapy (100%), compared to those without CMB (43%; RR 2.33 [95% CI 1.27, 4.27]). Those with CMB were also more likely to report a history of hypertension (100%) compared to those without (70%; RR 1.75 [95% CI 1.11, 2.75]). DLB core clinical features, cognition and functional status did not differ between the two groups. There was no association found between the presence of CMB and cortical Aβ deposition on PET imaging.
Conclusion:
CMB are not uncommon in DLB and may be associated with hypertensive small vessel disease. Further studies into the pathophysiology and clinical implications of CMB in DLB are needed.
Insights
Cerebral microbleeds (CMB) are present in 30% of dementia with Lewy bodies (DLB) patients, often linked to hypertension. CMB did not impact cognition or amyloid levels in this study.
Area of Science:
- Neurology
- Neuroimaging
- Geriatrics
Background:
- Cerebral microbleeds (CMB) are linked to cognitive decline and vascular conditions.
- The role of CMB in dementia with Lewy bodies (DLB) remains unclear.
Purpose of the Study:
- To determine the prevalence of CMB in DLB patients.
- To explore clinical associations of CMB in DLB.
Main Methods:
- Cross-sectional study of 20 DLB participants.
- 3T MRI for CMB assessment (SWI/QSM).
- Amyloid-beta (Aβ) PET imaging performed.
Main Results:
- CMB found in 30% of DLB participants, predominantly lobar.
- DLB with CMB more likely to have hypertension (100% vs 70%) and antithrombotic use (100% vs 43%).
- No significant differences in core DLB features, cognition, function, or Aβ deposition.
Conclusions:
- CMB are relatively common in DLB, potentially indicating hypertensive small vessel disease.
- Further research is needed on CMB pathophysiology and clinical impact in DLB.
