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The gut microbiome and obstructive sleep apnea syndrome in children

Wenxin Liu1, Qingqing Du1, Hong Zhang1

  • 1Children's Hospital of Shanghai Jiao Tong University, Clinical Lab in Children's Hospital of Shanghai, Shanghai, 200040, China; Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Jiao Tong University School of Medicine, 200062, Shanghai, China.

Sleep Medicine
|October 17, 2022
PubMed

Insights

Childhood obstructive sleep apnea syndrome (OSAS) disrupts the gut microbiome, impacting children's growth and health. This gut dysbiosis can lead to serious conditions like obesity and cardiovascular disease.

Area of Science:

  • Pediatric Health
  • Microbiome Research
  • Sleep Medicine

Background:

  • Obstructive sleep apnea syndrome (OSAS) is a growing public health concern affecting children's physical and mental development.
  • OSAS leads to intermittent hypoxia and sleep fragmentation, disrupting normal physiological functions.
  • The gut microbiome plays a crucial role in maintaining health and can be influenced by sleep disturbances.

Purpose of the Study:

  • To explore the mechanisms by which childhood OSAS alters the gut microbiota.
  • To investigate the pathophysiological consequences of these microbiome changes in children.
  • To review recent research on the OSAS-gut microbiota axis in pediatric populations.

Main Methods:

  • Review of current scientific literature on OSAS, gut microbiome, and pediatric health.
  • Analysis of studies investigating the impact of intermittent hypoxia and sleep fragmentation on gut bacteria.
  • Examination of research linking gut dysbiosis to comorbidities associated with childhood OSAS.

Main Results:

  • Childhood OSAS significantly alters gut microbiome composition.
  • Gut dysbiosis in OSAS is associated with impaired metabolic, cardiovascular, and immune system development.
  • Changes in the gut microbiome can exacerbate OSAS comorbidities like obesity and hypertension.

Conclusions:

  • Childhood OSAS-induced gut dysbiosis is a critical factor in pediatric pathophysiology.
  • Understanding this axis is vital for developing targeted interventions for affected children.
  • Further research is needed to elucidate the complex interplay between OSAS, the microbiome, and long-term health outcomes.

Keywords:
CGut microbiomeObstructive sleep apnea syndromehildren

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