Related Experiment Video
Updated: Aug 25, 2025

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Epigenetics: Promising journey so far but ways to go in head neck cancer
1MDS oral and maxillofacial surgery, Mahatma Gandhi Vidyamandir's Karmaveer Bhausaheb Hiray Dental College and Hospita, Nashik, India.
Abstract:
During the past decade, there has been a significant increase in knowledge regarding the molecular biology and epigenetics of head and neck carcer. Despite much effort to identify biomarkers for the early detection and development of new therapies for head and neck carcer, the overall survival and prognosis remain poor. Many studies show that epigenetic events play an important role in head and neck carcer development and progression, including DNA methylation, chromatin remodeling, histone posttranslational covalent modifications, and effects of non-coding RNA. Epigenetic modifications influence silencing of tumor suppressor genes by promoter hypermethylation, regulate transcription by microRNAs and changes in chromatin structure, or induce genome instability through hypomethylation. getting to better understand aberrant patterns of methylation may provide biomarkers for early detection and diagnosis, while knowledge about target genes of microRNAs may improve the therapy of head and neck carcer and extend overall survival.
More Related Videos
Related Concept Videos
Epigenetic Regulation
X-chromosome...
Histone Modification
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
Inheritance of Chromatin Structures
Cancers Originate from Somatic Mutations in a Single Cell
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Induced Pluripotent Stem Cells
Somatic...

