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Updated: Aug 25, 2025

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
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PAE ameliorates doxorubicin-induced cardiotoxicity via suppressing NHE1 phosphorylation and stimulating PI3K/AKT

Yaling Yin1, Qianqian Niu2, Hongyan Hou2

  • 1Sino-UK Joint Laboratory of Brain Function and Injury and Department of Physiology and Neurobiology, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, Chin; Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, College of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China.

International Immunopharmacology
|October 17, 2022
PubMed

Keywords:
DoxorubicinNHE1PI3K/Akt signaling pathwayPerillaldehyde

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