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Updated: Aug 25, 2025

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
Published on: July 25, 2022
Exosome-based vaccines and their position in next generation vaccines
Manica Negahdaripour1, Bahare Vakili2, Navid Nezafat1
1Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Pharmaceutical Sciences Research Center, Shiraz University of Medical Science, Shiraz, Iran.
Abstract:
Extracellular vesicles (EVs), which include exosomes as a subset, are generated by most cell types and play crucial roles in intercellular communication. Exosomes offer intriguing tools as potential vaccines due to their ability to deliver a wide range of antigens and immunomodulatory properties. Exosome-based vaccines have demonstrated promising results against different types of infectious diseases as well as cancers, both in vitro and in vivo. In this review, a number of studies on exosome-based vaccines are highlighted and relevant clinical trials are discussed.
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