Related Experiment Video
Updated: Aug 25, 2025
Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
Comparison of primary cytology, primary HPV testing and co-testing as cervical cancer screening for Chinese women: a
Zhi-Fang Li1,2, Xin-Hua Jia3,4, Xiangxian Feng2
1Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chaoyang District, Beijing, China qiaoy@cicams.ac.cn lzfmuzi@163.com.
Objectives:
We compared clinical performance of three strategies of primary human papillomavirus (HPV) testing, primary cytology and co-testing for cervical cancer screening.
Design:
A population-based prospective cohort study of clinical performance of screening strategy.
Setting:
Patients recruited from community in Changzhi County, Shanxi Province, China.
Patient:
3209 women aged 30-64 years without gynaecological issues.
Primary And Secondary Outcome Measures:
The performance of different screening strategies for detecting cervical intraepithelial neoplasia grade 2 or more severe (CIN2+).
Results:
A total of 53 CIN2+ and 31 CIN3+ cases are detected. For CIN2+, sensitivity of primary HPV (95.9%) and co-testing (98.0%) are not statistically different, but significantly higher than primary cytology (48.0%). Specificity (86.8%), colposcopy referral rate (7.8%) and number of colposcopies required to detect one case (9.8) for primary HPV are better than co-testing (79.8%, 11.9%, 14.3%, respectively). For CIN3+, primary HPV, co-testing have 100% of sensitivity and specificity, which is significantly higher than primary cytology (56.7% and 90.2%). Number of colposcopies required to detect one case for primary HPV (15.9) is better than co-testing (23.8).
Conclusions:
Compared with co-testing, HPV primary screening had comparable sensitivity and higher specificity for CIN2+ detection, and both of them showed better performance than cytology primary screening in cervical cancer screening.
More Related Videos
10:26RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
13:41Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012