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Therapeutic advances in COVID-19
Naoka Murakami1,2, Robert Hayden1,2, Thomas Hills3,4
1Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Nature Reviews. Nephrology
|October 17, 2022
Summary
COVID-19 treatments have evolved beyond early pandemic measures. Anti-inflammatory and antiviral drugs offer the most benefit, but kidney disease patients were underrepresented in trials.
Area of Science:
- Infectious Diseases
- Nephrology
- Pharmacology
Background:
- The COVID-19 pandemic necessitated rapid development of therapeutic strategies.
- Early treatment decisions relied on limited data; current options are evidence-based.
- Seven main categories of COVID-19 therapies are now available.
Purpose of the Study:
- To review the clinical evidence for major COVID-19 therapies.
- To analyze these treatments from a kidney medicine perspective.
- To highlight the importance of patient population characteristics in trial interpretation.
Main Methods:
- Systematic review of clinical evidence for COVID-19 therapies.
- Analysis of treatment efficacy based on patient populations and clinical settings.
- Focus on implications for patients with acute and chronic kidney disease.
Main Results:
- Anti-inflammatory and antiviral agents demonstrate the greatest magnitude of benefit.
- Novel SARS-CoV-2 variants complicate evidence interpretation, especially for antibody therapies.
- Patients with kidney disease were underrepresented in many COVID-19 trials.
Conclusions:
- Evidence-based therapies have significantly advanced COVID-19 management.
- Kidney disease patient outcomes may differ due to trial underrepresentation.
- A kidney medicine lens is crucial for understanding COVID-19 treatment efficacy in this population.
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