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Prevalence and coagulation correlation of anticardiolipin antibodies in patients with COVID-19

Hui Zeng1,2, Meihong Cai3, Han Xue2

  • 1Center of Clinical Laboratory, Hangzhou Ninth People's Hospital, Hangzhou, Zhejiang, China.

Medicine
|October 18, 2022
PubMed

Insights

Anticardiolipin antibodies (ACLs) were more prevalent in critically ill COVID-19 patients, particularly IgG isotype. However, ACLs showed weak correlation with coagulation variables and did not clearly link to thrombosis in these patients.

Area of Science:

  • Immunology
  • Hematology
  • Infectious Diseases

Background:

  • Anticardiolipin antibodies (ACLs) are associated with thrombotic events.
  • Coronavirus disease 2019 (COVID-19) is linked to coagulopathies.
  • The role of ACLs in COVID-19 pathogenesis requires further investigation.

Purpose of the Study:

  • To determine the prevalence and characteristics of ACLs in COVID-19 patients.
  • To correlate ACLs with laboratory coagulation variables.
  • To assess the association between ACLs and disease severity in COVID-19.

Main Methods:

  • Retrospective analysis of 87 COVID-19 patients.
  • Measurement of serum anticardiolipin antibodies (IgA, IgG).
  • Correlation analysis with coagulation parameters (aPTT, TT).

Main Results:

  • ACLs detected in 61.91% of critically ill vs. 31.82% of non-critically ill patients.
  • IgG isotype was significantly more prevalent in critically ill patients (OR=2.721).
  • ACLs-IgG showed weak correlations with activated partial thromboplastin time and thrombin time.

Conclusions:

  • ACLs, particularly IgG, are more common in severe COVID-19.
  • ACLs do not appear to strongly correlate with coagulation abnormalities or thrombosis in COVID-19 patients.
  • Further research is needed to elucidate the role of ACLs in COVID-19.

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