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Related Experiment Video

Updated: Aug 25, 2025

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
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Objective perimetry and progression of multiple sclerosis.

Ted Maddess1, Corinne F Carle1, Emilie M F Rohan1

  • 1Eccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University, Acton, ACT, Australia.

Eneurologicalsci
|October 18, 2022
PubMed
Summary

Multifocal pupillographic objective perimetry (mfPOP) can predict multiple sclerosis (MS) progression. Baseline visual field delays measured by mfPOP in persons with MS are associated with increased odds of future disease progression.

Keywords:
Disability progressionMultiple sclerosisObjective perimetryPupillary response

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Area of Science:

  • Ophthalmology
  • Neurology
  • Medical imaging

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease affecting the central nervous system.
  • Visual field deficits are common in MS and can impact patient quality of life.
  • Monitoring disease progression is crucial for effective management of MS.

Purpose of the Study:

  • To re-examine per-region response amplitudes and delays using multifocal pupillographic objective perimetry (mfPOP) after 10 years in persons with MS (PwMS).
  • To determine if baseline mfPOP data could predict the overall progression of MS.
  • To identify specific visual field regions where response properties have progressed.

Main Methods:

  • Longitudinal study of 44 persons with MS (PwMS) with mfPOP and Expanded Disability Status Scale (EDSS) assessments in 2009 and 2019.
  • mfPOP testing was performed on both eyes at 44 locations per eye.
  • Logistic regression was used to analyze the association between baseline mfPOP measures and clinical progression.

Main Results:

  • No significant change in mean EDSS scores was observed between 2009 and 2019.
  • mfPOP revealed a progressive delay from inferior to superior visual field regions and a temporal to nasal gradient in amplitudes.
  • The mean delay in the 3 most delayed visual field regions at baseline significantly correlated with MS progression (p=0.023).
  • A baseline delay of at least 1 SD (40 ms) in 3 regions was associated with 2.05 times higher odds of progression by 2019.

Conclusions:

  • mfPOP measurements, particularly visual field delays, can predict future multiple sclerosis progression.
  • mfPOP offers a rapid and convenient method for monitoring disease progression in PwMS.
  • Amplitude changes measured by mfPOP were not found to be predictive of MS progression.