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Related Experiment Video

Updated: Aug 25, 2025

Labelling and Visualization of Mitochondrial Genome Expression Products in Baker's Yeast Saccharomyces cerevisiae
08:33

Labelling and Visualization of Mitochondrial Genome Expression Products in Baker's Yeast Saccharomyces cerevisiae

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Storage Artifact Masquerading as Yeast: Presenting a Diagnostic Pitfall.

Elena M Fenu1, Tawfeq Naal1, Elizabeth Palavecino1

  • 1Department of Pathology, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.

Case Reports in Pathology
|October 18, 2022
PubMed
Summary
This summary is machine-generated.

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Prolonged storage of blood and body fluid samples can alter cell appearance. This nuclear pyknosis in neutrophils may mimic infections, leading to potential misdiagnosis.

Area of Science:

  • Hematology
  • Cytopathology

Background:

  • Cellular morphology is crucial for diagnosing infections and other conditions.
  • Specimen integrity is vital for accurate microscopic examination.

Observation:

  • Prolonged storage of blood and body fluid specimens can induce abnormal cell morphology.
  • Nuclear pyknosis in segmented neutrophils is a notable change, affecting both peripheral blood and body fluid samples.

Findings:

  • Nuclear pyknosis can be mistaken for intracellular microorganisms like yeast or bacteria.
  • This morphologic alteration poses a diagnostic challenge, particularly in body fluid analysis.

Implications:

  • Awareness of storage-induced changes is essential to prevent misdiagnosis of infections.

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  • Misidentification may lead to unnecessary investigations for fungal or bacterial infections.
  • Accurate interpretation requires differentiating artifact from true pathological findings.