Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

627
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
627

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Small Molecule Activators of Antitumor Immunity.

Accounts of chemical research·2026
Same author

Ectopic Tyrosinase Perturbs Cellular Iron Homeostasis.

ACS chemical biology·2026
Same author

Recent advances in site-specific modifications of peptides and proteins.

Chemical science·2026
Same author

Association between device-measured physical activity and aortic aneurysm risk: a prospective cohort study of 93165 UK biobank participants.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2026
Same author

Chemical Strategy and AI-Enabled Peptide Vaccine Development.

JACS Au·2026
Same author

Transcription factor c-Maf: a checkpoint that programs autoimmunity.

Frontiers in immunology·2025

Related Experiment Video

Updated: Aug 25, 2025

Evaluating the Immune Response of a Nanoemulsion Adjuvant Vaccine Against Methicillin-Resistant Staphylococcus aureus MRSA Infection
07:32

Evaluating the Immune Response of a Nanoemulsion Adjuvant Vaccine Against Methicillin-Resistant Staphylococcus aureus MRSA Infection

Published on: September 1, 2023

2.0K

Self-assembling small-molecule adjuvants as antigen nano-carriers.

Shuyu Jin1,2, Shao-Hua Zhuo3, Yasushi Takemoto2

  • 1Graduate School of Medicine, Kyoto University, Uji, Kyoto 611-0011, Japan.

Chemical Communications (Cambridge, England)
|October 18, 2022
PubMed
Summary

This study developed a novel subunit vaccine by conjugating peptide antigens with cholicamide, a self-assembling adjuvant. This approach enhances antigen presentation and immune response, addressing key vaccine development challenges.

More Related Videos

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
10:06

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Published on: September 2, 2022

1.9K
Author Spotlight: Development and Evaluation of a Cationic Nanoemulsion-Encapsulated Retinoic Acid System for Mucosal Vaccination
06:02

Author Spotlight: Development and Evaluation of a Cationic Nanoemulsion-Encapsulated Retinoic Acid System for Mucosal Vaccination

Published on: February 23, 2024

749

Related Experiment Videos

Last Updated: Aug 25, 2025

Evaluating the Immune Response of a Nanoemulsion Adjuvant Vaccine Against Methicillin-Resistant Staphylococcus aureus MRSA Infection
07:32

Evaluating the Immune Response of a Nanoemulsion Adjuvant Vaccine Against Methicillin-Resistant Staphylococcus aureus MRSA Infection

Published on: September 1, 2023

2.0K
Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
10:06

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Published on: September 2, 2022

1.9K
Author Spotlight: Development and Evaluation of a Cationic Nanoemulsion-Encapsulated Retinoic Acid System for Mucosal Vaccination
06:02

Author Spotlight: Development and Evaluation of a Cationic Nanoemulsion-Encapsulated Retinoic Acid System for Mucosal Vaccination

Published on: February 23, 2024

749

Area of Science:

  • Vaccinology
  • Immunology
  • Materials Science

Background:

  • Subunit vaccine development faces challenges in co-delivering antigens and adjuvants.
  • Achieving high levels of antigen presentation is crucial for vaccine efficacy.

Purpose of the Study:

  • To develop a novel strategy for effective co-delivery of antigens and adjuvants.
  • To enhance antigen presentation and immune potentiation in subunit vaccines.

Main Methods:

  • Conjugating peptide antigens with cholicamide, a self-assembling small molecule adjuvant.
  • Forming co-assemblies of the antigen-cholicamide conjugates and free cholicamide.

Main Results:

  • The co-assemblies demonstrated high levels of cytokine induction.
  • Enhanced major histocompatibility complex (MHC) class II peptide presentation was observed.
  • The self-assembling nature of cholicamide facilitated effective co-delivery.

Conclusions:

  • Conjugating antigens with self-assembling adjuvants is a promising strategy for subunit vaccine development.
  • This approach effectively addresses the challenges of co-delivery and antigen presentation.
  • The developed system shows potential for improved vaccine efficacy.