Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

Pathophysiology of Diabetes

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Vanin-1 deficiency enhances host tolerance to influenza infection by modulating cellular redox status.

PNAS nexus·2026

Same author

Multi-Layered Mechanisms of Immunological Tolerance at the Maternal-Fetal Interface.

Immune network·2024

Same author

Induction of natural IgE by glucocorticoids.

The Journal of experimental medicine·2022

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 25, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Developmental Programming by Perinatal Glucocorticoids.

Jun Young Hong¹

¹Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.

Molecules and Cells

|October 18, 2022

Summary

Early environmental exposures can program long-term health in mammals. Perinatal glucocorticoids, a key factor, persistently affect metabolic, behavioral, and immune functions into adulthood.

Keywords:

adaptation developmental endocrine developmental programming glucocorticoids perinatal period stress

More Related Videos

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Related Experiment Videos

Last Updated: Aug 25, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Area of Science:

Developmental biology
Endocrinology
Environmental health

Background:

Early-life environmental factors significantly impact long-term physiological functions.
Developmental programming is increasingly recognized in mammals, affecting human health.
Endocrine glucocorticoids are emerging as critical mediators in developmental programming.

Purpose of the Study:

To review recent findings on developmental programming by perinatal glucocorticoids.
To discuss the biological mechanisms underlying long-term programming effects.
To highlight the influence of early-life exposures on adult health outcomes.

Main Methods:

Literature review of experimental and epidemiological studies.
Synthesis of current research on glucocorticoid-mediated developmental programming.
Discussion of proposed molecular and physiological mechanisms.

Main Results:

Perinatal glucocorticoids induce persistent changes in metabolic, behavioral, and immune functions.
Evidence supports developmental programming as a key mechanism linking early-life factors to adult health.
Multiple biological pathways are implicated in mediating these long-term effects.

Conclusions:

Developmental programming by perinatal glucocorticoids has profound and lasting impacts on mammalian physiology.
Understanding these mechanisms is crucial for preventing and treating non-communicable diseases.
Further research is needed to fully elucidate the biological rationale and therapeutic targets.