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Nickel-Catalyzed Site-Selective Intermolecular C(sp3 )-H Amidation
Jinhong Chen1,2, Hao Wang1,2, Craig S Day1,2
1Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007, Tarragona, Spain.
Researchers developed a nickel-catalyzed method for site-selective amidation of C(sp3)-H bonds. This approach efficiently introduces amide groups near nitrogen or oxygen atoms in various molecular structures.
Area of Science:
- Organic Chemistry
- Catalysis
- Synthetic Methodology
Background:
- C(sp3)-H bond functionalization is crucial for molecule synthesis.
- Existing methods for C(sp3)-H amidation often lack site-selectivity or require harsh conditions.
- Developing selective and mild methods for incorporating amide functionalities remains a challenge.
Purpose of the Study:
- To report a novel nickel-catalyzed intermolecular amidation of saturated C(sp3)-H bonds.
- To achieve site-selective functionalization adjacent to heteroatoms (N, O).
- To offer a complementary approach to existing C-H activation and C-N bond-forming reactions.
Main Methods:
- Nickel-catalyzed reaction.
- Intermolecular amidation.
- Focus on saturated C(sp3)-H bonds adjacent to N or O atoms.
Main Results:
- Successful site-selective amidation of C(sp3)-H bonds was achieved.
- The protocol demonstrated predictable reactivity patterns.
- Amide groups were incorporated into cyclic and acyclic frameworks near nitrogen and oxygen.
Conclusions:
- A mild and site-selective nickel-catalyzed amidation of C(sp3)-H bonds has been established.
- This method provides a valuable tool for incorporating amide functionalities.
- The protocol complements existing strategies for C(sp3)-H functionalization and C-N bond formation.
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