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Updated: Aug 25, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Bullous skin diseases]
Jeanette Kaae1, Rikke Bech2, Elisabeth Hjardem Taudorf1
1Dermatologisk Afdeling, Sjællands Universitetshospital, Roskilde.
Abstract:
This review finds that topical corticosteroids and systemic corticosteroids are the mainstays of initial treatment for bullous pemphigoid and pemphigus diseases. Additional immunomodulatory therapies such as methotrexate, azathioprine and mycophenolatmofetil should be added early during treatment to minimize the adverse effects of chronic corticosteroid therapy and to augment improvement in the disease. Rituximab is a first-line immunomodulatory treatment for moderate to severe pemphigus disease.
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