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Curcumin-based ionic Pt(II) complexes: antioxidant and antimicrobial activity.
Rossella Caligiuri1, Giuseppe Di Maio1, Nicolas Godbert1
1MAT-INLAB, LASCAMM CR-INSTM, Unità INSTM della Calabria, Dipartimento di Chimica e Tecnologie Chimiche, Università della Calabria, 87036 Arcavacata di Rende, CS, Italy. iolinda.aiello@unical.it.
Dalton Transactions (Cambridge, England : 2003)
|October 18, 2022
Summary
Novel platinum(II) complexes with curcumin demonstrated significant antioxidant and antibacterial properties. These findings suggest potential therapeutic applications for these new platinum-curcumin compounds.
Area of Science:
- Inorganic Chemistry
- Medicinal Chemistry
- Computational Chemistry
Background:
- Curcumin is a natural compound with known antioxidant and anti-inflammatory properties.
- Platinum(II) complexes are widely studied for their anticancer and antimicrobial activities.
- There is a need for novel therapeutic agents with enhanced efficacy and reduced toxicity.
Purpose of the Study:
- To synthesize and characterize novel cationic curcumin-based platinum(II) complexes.
- To evaluate the antioxidant radical scavenging activity of these complexes.
- To investigate the in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli.
Main Methods:
- Synthesis and full characterization of four novel platinum(II) complexes.
- Spectrophotometric measurement of antioxidant activity using DPPH assay.
- In vitro antibacterial testing using the disk diffusion method.
- Computational studies to elucidate antioxidant mechanisms.
Main Results:
- The synthesized platinum(II) complexes exhibited notable antioxidant radical scavenging activity.
- Compounds 1-4 demonstrated in vitro growth inhibitory effects against both Staphylococcus aureus and Escherichia coli.
- Computational analysis provided insights into the antioxidant mechanisms of curcumin and its platinum(II) complexes.
Conclusions:
- The complexation of curcumin with platinum(II) enhances its biological activities.
- These novel platinum(II) complexes show promise as potential antimicrobial and antioxidant agents.
- Further research is warranted to explore their therapeutic potential.
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