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Related Concept Videos

EDTA: Auxiliary Complexing Reagents01:26

EDTA: Auxiliary Complexing Reagents

648
EDTA titrations are usually carried out in highly basic conditions, where the fully deprotonated form of EDTA, Y4−, actively complexes with the free metal ions in the solution. Several metal ions precipitate as hydrous oxide (hydroxides, oxides, or oxyhydroxides) under these conditions, lowering the concentration of free metal ions in the solution. For this reason, auxiliary complexing agents or ligands such as ammonia, tartrate, citrate, or triethanolamine are used in EDTA titrations to...
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EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

2.1K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
2.1K
Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

1.1K
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
1.1K
Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

457
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
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Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

615
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
615
Formation of Complex Ions03:45

Formation of Complex Ions

23.9K
A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
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Curcumin-based ionic Pt(II) complexes: antioxidant and antimicrobial activity.

Rossella Caligiuri1, Giuseppe Di Maio1, Nicolas Godbert1

  • 1MAT-INLAB, LASCAMM CR-INSTM, Unità INSTM della Calabria, Dipartimento di Chimica e Tecnologie Chimiche, Università della Calabria, 87036 Arcavacata di Rende, CS, Italy. iolinda.aiello@unical.it.

Dalton Transactions (Cambridge, England : 2003)
|October 18, 2022
PubMed
Summary
This summary is machine-generated.

Novel platinum(II) complexes with curcumin demonstrated significant antioxidant and antibacterial properties. These findings suggest potential therapeutic applications for these new platinum-curcumin compounds.

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Area of Science:

  • Inorganic Chemistry
  • Medicinal Chemistry
  • Computational Chemistry

Background:

  • Curcumin is a natural compound with known antioxidant and anti-inflammatory properties.
  • Platinum(II) complexes are widely studied for their anticancer and antimicrobial activities.
  • There is a need for novel therapeutic agents with enhanced efficacy and reduced toxicity.

Purpose of the Study:

  • To synthesize and characterize novel cationic curcumin-based platinum(II) complexes.
  • To evaluate the antioxidant radical scavenging activity of these complexes.
  • To investigate the in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli.

Main Methods:

  • Synthesis and full characterization of four novel platinum(II) complexes.
  • Spectrophotometric measurement of antioxidant activity using DPPH assay.
  • In vitro antibacterial testing using the disk diffusion method.
  • Computational studies to elucidate antioxidant mechanisms.

Main Results:

  • The synthesized platinum(II) complexes exhibited notable antioxidant radical scavenging activity.
  • Compounds 1-4 demonstrated in vitro growth inhibitory effects against both Staphylococcus aureus and Escherichia coli.
  • Computational analysis provided insights into the antioxidant mechanisms of curcumin and its platinum(II) complexes.

Conclusions:

  • The complexation of curcumin with platinum(II) enhances its biological activities.
  • These novel platinum(II) complexes show promise as potential antimicrobial and antioxidant agents.
  • Further research is warranted to explore their therapeutic potential.