Related Experiment Video
Updated: Aug 25, 2025
Author Spotlight: An Automated Method for Assessing Visual Acuity in Infants and Toddlers Using an Eye-Tracking System
Published on: March 17, 2023
Ocular Perfusion Pressure in 7- and 12-Year-Old Chinese Children: The Anyang Childhood Eye Study
Wei-Ling Bai1, Yu-Ting Kang1, Shi-Ming Li1
1Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Laboratory, Beijing, China.
Insights
Mean ocular perfusion pressure (MOPP) was higher in older Chinese children and associated with less myopia. Higher MOPP may help detect myopia development, indicating its potential as an early indicator.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Public Health
Background:
- Childhood myopia is a growing public health concern.
- Understanding ocular perfusion pressure (MOPP) is crucial for eye health.
- Factors influencing MOPP in children require further investigation.
Purpose of the Study:
- To determine the distribution of Mean Ocular Perfusion Pressure (MOPP) in Chinese children.
- To identify factors associated with MOPP in a pediatric population.
- To explore the relationship between MOPP and myopia development.
Main Methods:
- The Anyang Childhood Eye Study enrolled 3048 grade 1 and 2258 grade 7 students.
- Ocular perfusion pressure was calculated using blood pressure and intraocular pressure measurements.
- Risk factors for myopia were assessed via questionnaire.
Main Results:
- Mean MOPP was 33.83 ± 6.37 mm Hg in grade 1 and 36.99 ± 6.80 mm Hg in grade 7.
- Higher MOPP was observed in non-myopic eyes compared to myopic eyes in grade 7.
- Multivariable analysis linked higher MOPP to older age, higher BMI, thinner cornea, less near work, and more sleep.
Conclusions:
- Mean ocular perfusion pressure increases with age in Chinese children.
- MOPP is associated with several factors including myopia, BMI, and lifestyle habits.
- MOPP may serve as a potential indicator for detecting myopia development in children.
Purpose:
The purpose of this study was to report the distribution of mean ocular perfusion pressure (MOPP) and its associated factors in Chinese children.
Methods:
We enrolled 3048 grade 1 students and 2258 grade 7 students of the Anyang Childhood Eye Study in central China. Systolic and diastolic blood pressure (SBP and DBP) were recorded with a digital automatic sphygmomanometer. Intraocular pressure (IOP) was assessed by a non-contact tonometer. MOPP was calculated as 2/3 × (DBP + 1/3[SBP - DBP]) - IOP. Risk factors for myopia were obtained through a questionnaire survey.
Results:
The MOPP was 33.83 ± 6.37 mm Hg (mean ± SD) in grade 1, which was lower than 36.99 ± 6.80 mm Hg in grade 7 (P < 0.001). Compared with myopic eyes, non-myopic eyes had higher MOPP in grade 7 (37.72 ± 6.72 mm Hg versus 36.58 ± 6.57 mm Hg, P < 0.001) and in grade 1 (33.88 ± 6.29 mm Hg versus 33.12 ± 7.03 mm Hg, P = 0.12). Multivariable analysis showed that higher MOPP was associated with less myopia (P < 0.001), higher body mass index (BMI; P < 0.001), thinner central corneal thickness (P < 0.001), less time on near work (P < 0.001), and more time on sleeping (P = 0.04).
Conclusions:
MOPP was higher in children of older age, with higher BMI, less time on near work, and more time on sleeping, and was higher in eyes with less myopia.
Translational Relevance:
We found that MOPP might be an indicator for the detection of myopia development.
