Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

362
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
362
Allergic Drug Reactions01:27

Allergic Drug Reactions

936
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
936
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

189
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
189
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

280
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
280
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

404
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
404
Allergic Reactions02:06

Allergic Reactions

28.2K
Overview
28.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Assessment and Clinical Management of Patients With Atopic Dermatitis Undergoing Patch Testing: Recommendations From an International Electronic Delphi Consensus.

Dermatitis : contact, atopic, occupational, drug·2026
Same author

Worth their weight in gray matter? A narrative review of cost-effectiveness analyses of monoclonal antibodies for Alzheimer's disease.

Alzheimer's & dementia (New York, N. Y.)·2026
Same author

<i>Letter:</i> Demographics of Positive Patch Test Reactions to Propylene Glycol.

Dermatitis : contact, atopic, occupational, drug·2026
Same author

Guidelines of care for the management of atopic dermatitis in pediatric patients.

Journal of the American Academy of Dermatology·2026
Same author

Guidelines of care for the primary prevention of atopic dermatitis and awareness of comorbid conditions in pediatric atopic dermatitis.

Journal of the American Academy of Dermatology·2026
Same author

Improved Investigator Global Assessment, Allergic Contact Dermatitis-11, Dermatology Life Quality Index, and Global Quality of Life and Severity Scores after Patch Testing in Dermatitis Patients.

Dermatitis : contact, atopic, occupational, drug·2026
Same journal

The Toxin of the Year: Airborne PM<sub>2.5</sub>.

Dermatitis : contact, atopic, occupational, drug·2026
Same journal

Eyelid Dermatitis: A 5-Year Retrospective Review from a Metropolitan Contact Dermatitis Clinic.

Dermatitis : contact, atopic, occupational, drug·2026
Same journal

<i>Letter:</i> Anogenital Dermatitis Rarely Occurs in Isolation: Disease Distribution and Delays in Patch Testing.

Dermatitis : contact, atopic, occupational, drug·2026
Same journal

Practical Techniques: Photopatch Testing.

Dermatitis : contact, atopic, occupational, drug·2026
Same journal

Digital Image Superimposition for Identifying Delayed Patch Test Reactions: A Clinical Pearl.

Dermatitis : contact, atopic, occupational, drug·2026
See all related articles

Related Experiment Video

Updated: Aug 25, 2025

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
06:31

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

8.7K

Systematic Review of Systemic Corticosteroid Effects on Patch Testing.

Penelope Kim-Lim, Ebba Wennberg, Megan Van Noord1

  • 1School of Medicine, University of California, Davis, Sacramento, CA.

Dermatitis : Contact, Atopic, Occupational, Drug
|October 18, 2022
PubMed
Summary
This summary is machine-generated.

Systemic corticosteroids like prednisone can reduce the intensity of allergic contact dermatitis patch test reactions. This review found that while not linear, higher prednisone doses generally led to diminished or negated patch test responses.

More Related Videos

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

9.7K
Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

19.3K

Related Experiment Videos

Last Updated: Aug 25, 2025

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
06:31

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

8.7K
Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

9.7K
Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

19.3K

Area of Science:

  • Dermatology
  • Allergology
  • Clinical Pharmacology

Background:

  • Systemic corticosteroids are frequently prescribed for inflammatory skin conditions, including allergic contact dermatitis.
  • Patch testing is a crucial diagnostic tool for identifying contact allergens.

Approach:

  • This systematic review analyzed the impact of varying daily doses of systemic corticosteroids (prednisone: 20, 30, and 40 mg) on patch test reaction presence and intensity.
  • The study compared reactions in patients receiving corticosteroid therapy versus those not.

Key Points:

  • The relationship between prednisone dosage and reaction outcomes (retained, diminished, negated) was not strictly linear.
  • A significant trend (P < 0.0001) indicated lower intensity patch test reactions in patients undergoing prednisone therapy across all evaluated doses.
  • Corticosteroid use demonstrably influences patch test results.

Conclusions:

  • Systemic corticosteroid therapy, particularly prednisone, can modulate the sensitivity and intensity of patch test reactions.
  • Findings suggest that current corticosteroid use should be considered when interpreting patch test results.
  • Further research is warranted to elucidate the precise mechanisms and clinical implications of corticosteroid effects on patch testing.