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A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
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A Facile Structural Isomerization-Induced 3D Spatial D-A Interlocked Network for Achieving NIR-II Phototheranostic
Lina Feng1, Chunbin Li1, Lingxiu Liu1
1College of Chemistry and Chemical Engineering, Inner Mongolia Key Laboratory of Fine Organic Synthesis, Inner Mongolia University, Hohhot, 010021, P. R. China.
Angewandte Chemie (International Ed. in English)
|October 18, 2022
Summary
Researchers developed novel organic phototheranostic agents (OPTAs) for second near-infrared (NIR-II) imaging and therapy. A specific isomer, 6MNVDPP, demonstrated superior performance in preclinical cancer models due to its unique molecular structure and packing.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Organic phototheranostic agents (OPTAs) performance is influenced by molecular structure and packing in nanoparticles (NPs).
- Developing efficient NIR-II OPTAs is crucial for advanced medical imaging and therapy.
Purpose of the Study:
- To design and synthesize novel NIR-II OPTAs using structural isomerization-induced 3D spatial donor-acceptor (D-A) interlocked networks.
- To investigate the structure-property relationships of two isomers (4MNVDPP and 6MNVDPP) for NIR-II phototheranostics.
- To evaluate the in vivo efficacy of the optimized OPTA NPs for cancer imaging and synergistic therapy.
Main Methods:
- Synthesis of two isomers: 4MNVDPP and 6MNVDPP.
- Formulation of isomers into nanoparticles (NPs).
- Characterization of NP properties including NIR absorption, photothermal conversion efficiency, and reactive oxygen species (ROS) generation.
- In vivo evaluation of NIR-II imaging and anti-cancer therapeutic effects.
Main Results:
- 6MNVDPP exhibited a compact 3D spatial D-A interlocked network, unlike 4MNVDPP's 2D D-D J-aggregates.
- 6MNVDPP NPs showed red-shifted NIR absorption, higher molar extinction coefficient, and 89% photothermal conversion efficiency.
- 6MNVDPP NPs demonstrated superior NIR-II imaging of tiny capillary vasculature and tumors, along with effective synergistic photothermal/photodynamic therapy in vivo.
Conclusions:
- Structural isomerization and 3D D-A interlocked network formation are effective strategies for enhancing NIR-II OPTA performance.
- 6MNVDPP NPs represent a promising theranostic platform for advanced cancer treatment.
- The study highlights the importance of molecular design and packing for optimizing phototheranostic agents.
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