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HPV infection profile in cervical lesions
Beatriz González-Yebra1, Miriam Mojica-Larrea1, Ruth Alonso2
1Department of Medicine and Nutrition, Division of Health Sciences, Universidad de Guanajuato, Campus León, Guanajuato.
Gaceta Medica De Mexico
|October 18, 2022
Summary
Multiple human papillomavirus (HPV) infections were common in cervical lesions in Mexico. This HPV heterogeneity contrasts with global data and may impact HPV vaccination strategies.
Area of Science:
- Gynecology
- Virology
- Oncology
Background:
- Human papillomavirus (HPV) genotype prevalence varies by lesion severity and geographic location.
- Understanding regional HPV distribution is crucial for effective cervical cancer prevention.
Purpose of the Study:
- To identify multiple HPV infections in low- and high-grade cervical lesions.
- To analyze HPV genotypes in women with inconclusive cytology from Mexico's Bajío region.
Main Methods:
- Pilot study involving women with cervical lesions from Guanajuato, Mexico.
- DNA extraction and HPV genotyping using microarrays on cervical smears.
Main Results:
- HPV was detected in 26% of healthy women and 62% with cervical lesions.
- HPV genotypes 59, 31, 16, and 51 were most prevalent.
- Multiple HPV infections were frequent, particularly in precursor lesions.
Conclusions:
- Significant HPV heterogeneity and multiple infections were observed in the study population.
- Multiple infections were more common in precursor lesions than high-grade lesions.
- Findings may influence current HPV vaccination programs and cervical cancer screening.
Keywords:
Cervical lesionsGenotipos de VPHHPV genotypesHPV prevalenceHuman papilloma virusLesiones cervicalesPrevalencia de VPHVirus de papiloma humanoMore Related Videos
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