Pyrrole-2-carbaldehydes with neuroprotective activities from Moringa oleifera seeds
Yueping Jiang1, Rong Liu1, Jing Li1
1Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China; Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Abstract:
Seven undescribed pyrrole-2-carbaldehydes (pyrrolemorines A-G), along with four known analogs, were isolated from the aqueous extract of Moringa oleifera seeds. The structures were elucidated by comprehensive spectroscopic and chemical analyses using HRMS and NMR spectra, acid hydrolysis, and Rh2(OCOCF3)4-induced ECD experiments. Pyrrolemorines A, E, and pyrrolemarumine displayed neuroprotective activities against oxygen-glucose deprivation/reperfusion injury in PC12 cells by regulating NF-κb and Nrf2.
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