Related Experiment Video
Updated: Aug 25, 2025
12:22
The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
33.7K
Epigenetics in advanced renal cell carcinoma: Potential new targets
Javier Molina-Cerrillo1, Matteo Santoni2, Álvaro Ruiz1
1Medical Oncology Department, Hospital Universitario Ramón y Cajal, Medicine School, Alcalá University, Madrid, Spain.
Critical Reviews in Oncology/Hematology
|October 18, 2022
Summary
Epigenetic aberrations drive renal cell carcinoma (RCC) development. Epigenetic drugs show promise for treating advanced kidney cancer when other therapies fail.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Renal cell carcinoma (RCC) is a significant cause of cancer death in Europe.
- Current treatments like angiogenesis inhibitors and immunotherapies (PD-1/PDL-1, CTLA-4) are effective but often face patient progression.
- Epigenetic alterations, such as promoter methylation and microRNA dysregulation, play a crucial role in RCC development by altering gene expression without changing the DNA sequence.
Purpose of the Study:
- To review key epigenetic alterations in RCC.
- To explore the involvement of these alterations in pathological signaling pathways.
- To highlight epigenetics as a potential therapeutic target for advanced RCC.
Main Methods:
- Literature review of epigenetic modifications in renal cell carcinoma.
- Analysis of signaling pathways influenced by epigenetic aberrations.
- Evaluation of emerging epigenetic drugs for kidney cancer treatment.
Main Results:
- Epigenetic changes are common in RCC and contribute to its pathogenesis.
- These epigenetic modifications offer novel targets for therapeutic intervention.
- Epigenetic drugs are under early development and show potential for future RCC treatment.
Conclusions:
- Epigenetic alterations are fundamental to RCC development and progression.
- Targeting epigenetic modifications represents a promising new strategy for advanced kidney cancer.
- Further research into epigenetic therapies could significantly improve patient outcomes.
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