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A new human trophoblast antigen isolated from immune complexes derived from placental blood and membranes
Immune complexes were prepared from human trophoblast membranes, placental blood serum, non-pregnant female serum and normal male serum by precipitation, gel filtration and affinity chromatography. The purified complexes were subjected to analysis by SDS-PAGE and one common antigenic species was identified. This antigen (mol. wt. 82.8 +/- 2.4 K) was designated the putative trophoblast antigen (TA) and shown to exhibit discrete antigenic homology with human immunoglobulin and HLA molecules.
Immune complexes were prepared from human trophoblast membranes, placental blood serum, non-pregnant female serum and normal male serum by precipitation, gel filtration and affinity chromatography. The purified complexes were subjected to analysis by SDS-PAGE and one common antigenic species was identified. This antigen (mol. wt. 82.8 +/- 2.4 K) was designated the putative trophoblast antigen (TA) and shown to exhibit discrete antigenic homology with human immunoglobulin and HLA molecules.