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Ventricular depolarization and repolarization variability in children with type 1 diabetes mellitus

Diğdem Bezen1, Yelda Türkmenoğlu2, Ahmet İrdem3

  • 1Department of Pediatrics, Pediatric Endocrinology, University of Health Sciences, Prof. Dr. Cemil Taşçıoğlu City Hospital, İstanbul, Turkey.

Pediatrics International : Official Journal of the Japan Pediatric Society
|October 18, 2022
PubMed

Insights

Children with type 1 diabetes mellitus show atrial conduction delays and impaired ventricular repolarization. This study found a predisposition to pulmonary artery hypertension, but poor glycemic control did not increase left ventricle issues.

Area of Science:

  • Cardiology
  • Pediatrics
  • Endocrinology

Background:

  • Type 1 diabetes mellitus (T1DM) is associated with cardiac autonomic neuropathy, potentially affecting heart function.
  • Arrhythmias in T1DM patients may indicate underlying cardiac issues.
  • Evaluating cardiac parameters in pediatric T1DM is crucial for early detection of complications.

Purpose of the Study:

  • To assess pulmonary artery pressure in children with T1DM.
  • To evaluate ventricular depolarization and repolarization variability in pediatric T1DM.
  • To investigate the impact of glycemic control on cardiac parameters in T1DM.

Main Methods:

  • Investigated 78 children with T1DM and 68 healthy controls.
  • Subgrouped T1DM patients based on glycated hemoglobin (HbA1c) and disease duration.
  • Performed electrocardiograms (ECG) and transthoracic echocardiograms.

Main Results:

  • T1DM patients exhibited prolonged P, Pd, PR, QTc, QTd, QTcd, JT, JTc, JTd, and Tp-Te intervals and ratios.
  • Pulmonary artery pressure was significantly higher in T1DM patients.
  • The HbA1c ≥9% subgroup showed prolonged QTc and increased left ventricle dimensions, though not correlated with HbA1c after age adjustment.

Conclusions:

  • Children with T1DM experience atrial conduction delays and impaired ventricular repolarization.
  • There is an increased risk of pulmonary artery hypertension in pediatric T1DM.
  • Poor glycemic control did not correlate with left ventricle hypertrophy or dysfunction.
Abstract

Keywords:
atrial conductionchildhoodpulmonary artery pressuretype 1 diabetes mellitusventricular repolarization

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