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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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Human papillomavirus in men

Sergio Isidro Gamboa-Hoil1

  • 1Oncology, Unidad Médica de Alta Especialidad, Instituto Mexicano del Seguro Social, Mérida, Mexico.

Revista Internacional De Andrologia
|October 18, 2022
PubMed
Abstract

Insights

Human papillomavirus (HPV) DNA prevalence in men is 50.8%, with high-risk types like HPV-16 being most common. HPV infection is an independent prognostic factor for penile cancer survival.

Area of Science:

  • Oncology
  • Virology
  • Dermatology

Background:

  • Human papillomavirus (HPV) is a common sexually transmitted infection.
  • Certain HPV types are associated with an increased risk of various cancers, including penile cancer.
  • Understanding HPV's clinical behavior in men is crucial for prevention and treatment strategies.

Purpose of the Study:

  • To describe the clinical behavior of human papillomavirus (HPV) in men.
  • To review the international literature on HPV prevalence and its association with penile cancer.

Main Methods:

  • A comprehensive review of current international literature was conducted.
  • Data on HPV DNA prevalence, specific HPV types, and their association with penile cancer were analyzed.

Main Results:

  • The overall prevalence of HPV DNA in men is 50.8%.
  • Prevalence of HPV DNA in invasive penile cancer ranges from 33.1% to 47%, with HPV-16 being the most frequent type (68.3%).
  • Positive HPV status is an independent prognostic factor for cancer-specific survival.

Conclusions:

  • While the exact reasons for HPV predilection in specific genital areas remain unclear, risk factors for HPV infection are recognized.
  • HPV infection significantly impacts penile cancer prognosis.
  • Further research into HPV's clinical behavior in men is warranted.
Keywords:
Cáncer de peneHuman papillomavirusNeoplasias de penePenile cancerPenile neoplasmsVirus del papiloma humano

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