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Updated: Aug 25, 2025
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
Published on: July 5, 2021
Metastatic skull base chordoma: A systematic review
Kurtis Young1, Torbjoern Nielsen1, Hannah Bulosan1
1University of Hawai'i at Mānoa John A. Burns School of Medicine Honolulu Hawaii USA.
Objective/Hypothesis:
To investigate the clinical features, management strategies and outcomes for patients with metastatic primary skull base chordomas.
Study Design:
Systematic review.
Methods:
A systematic search through Pubmed/Medline, Web of Science, and EBSCOhost (CINAHL) was conducted without restriction on dates. After study screening and full-text assessment, two authors independently extracted all data using a pre-established abstraction form.
Results:
Forty cases were included from 38 studies. The average age (standard deviation [SD]) of the sample at presentation was 28.5 (23.3) and was equally distributed across genders. The average time (SD) between initial diagnosis to local recurrence was 40.1 (60.3) months. The average time (SD) from primary tumor detection to the diagnosis of metastatic disease was 55.2 (49.0) months. The most common subsite for metastatic spread were the lungs (32.5%). Of the 33 patients with data on outcomes, 48.5% were found to have expired by the time of publication. The median overall survival was estimated to be 84 months (95% confidence interval [CI] 62.3-105.7).
Conclusions:
The most common subsites for metastatic spread of skull base chordoma were the lungs and bone. Overall survival for patients in the current cohort was a median of 84 months, with no significant differences noted when stratifying by the extent of surgery or the site of metastases.
Level Of Evidence:
3a.
