Related Experiment Video
Updated: Aug 25, 2025

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
Published on: August 24, 2019
Effect of Physical Activity Program on the Quality of Life of Children with Cystic Fibrosis at School Age: A
Ashrafalsadat Hakim1, Seyedeh Kowsar Tabatabaei2, Seyed Mohammad Reza Mirkarimi3
1Nursing Care Research Center in Chronic Diseases, Department of Nursing, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Insights
A physical activity program (PAP) significantly improved the quality of life for children with cystic fibrosis (CF). This intervention demonstrated feasibility and effectiveness in enhancing physical, emotional, social, and academic aspects for children with CF.
Area of Science:
- Pediatrics
- Public Health
- Exercise Science
Background:
- Cystic fibrosis (CF) is a serious inherited disorder with significant mortality.
- Children with CF often experience reduced quality of life due to the disease's impact.
Purpose of the Study:
- To evaluate the impact of a physical activity program (PAP) on the quality of life in school-aged children with CF.
- To determine the feasibility and effectiveness of PAP as an intervention for pediatric CF patients.
Main Methods:
- A randomized controlled trial involving 70 children with CF, divided into intervention and control groups.
- Data collected using demographic questionnaires and the Pediatric Quality of Life Inventory.
- Statistical analysis included Chi-square, independent t-tests, and paired t-tests (p<0.05).
Main Results:
- No significant demographic or baseline quality of life differences between groups.
- The intervention group showed significant improvements in physical, emotional, social, and academic quality of life post-PAP (P<0.001).
- The control group exhibited no significant changes in quality of life before and after the study period.
Conclusions:
- Physical activity programs are effective in enhancing the quality of life for children with cystic fibrosis.
- PAP is a feasible and beneficial intervention for improving the overall well-being of pediatric CF patients.
Background:
Cystic fibrosis (CF) is a hereditary disease with a high mortality rate. The present study aimed to determine the effect of a physical activity program (PAP) on the life quality of children with CF at school age.
Materials And Methods:
This study conducted on 70 children with CF, the samples were randomly divided into intervention and control groups. A demographic information questionnaire and the Pediatric Quality of Life Inventory were used for data collection. This study was conducted in three stages and 2 months after the last intervention. Finally, the data were analyzed in SPSS software version 22 using the Chi-square test, independent t-test, and paired t-test at a p-value of less than 0.05.
Results:
The results indicated that the two groups had no significant difference in terms of demographic variables before the intervention. Moreover, it was observed that the mean scores of life quality in the physical, emotional, social, and academic performance of children in both groups before the intervention in child and parent evaluations did not show significant differences. After the intervention in the experimental group, the mean scores of life quality in all aspects significantly increased, compared to those of the control group (P<0.001). Moreover, there were no significant differences between the mean scores of life quality in the control group before and after the intervention.
Conclusion:
Given the effectiveness of the intervention to enhance life quality, PAP is feasible and possible in the field of CF. It has to be noted that this method is an effective way to improve life quality.
Related Concept Videos
Cystic Fibrosis: Management
Sinus disease and chronic...
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...

