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Simplified Human Neutrophil Extracellular Traps NETs Isolation and Handling
Published on: April 16, 2015
Neutrophil Extracellular Traps (NET) and SARS-CoV-2
1Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abstract:
NETosis is a type of neutrophil extinction that outcome in the liberation of extracellular chromatin and protein accumulation, which contains antiviral proteins, produced by an external pathogen. Neutrophils can show bipolar action in special circumstances. This event, along with other circumstances, involves COVID-19. Neutrophil extracellular traps (NETs) are involved in the pathogenesis of COVID-19 by creating a pro-inflammatory and pre-coagulation state that leads to numerous organ losses. This form of host defense, which is promoted by neutrophils, is closely related to the known cytokine storm in severe COVID-19 patients. Hence, these two elements reveal possibly the treatment of the target for SARS-CoV-2 infections intense.
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