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Efficacy and Safety of Methylprednisolone for Lung Surgery: a Systematic Review and Meta-analysis of Randomized

Xi Fu1, Xin Ye2, Li-Na An3

  • 1Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu, 610072, Sichuan, China.

Pain and Therapy
|October 19, 2022
PubMed
Abstract

Insights

Methylprednisolone (MP) offers no clinically significant pain relief after lung surgery, despite reducing inflammation markers. Further research is needed to explore its role in preventing complications.

Area of Science:

  • Anesthesiology and Critical Care Medicine
  • Pharmacology
  • Thoracic Surgery

Background:

  • Methylprednisolone (MP) is used in multimodal analgesia to manage postoperative pain and reduce opioid use.
  • A systematic evaluation of MP's efficacy and safety in lung surgery is currently lacking.
  • This study addresses the need for a comprehensive review of perioperative MP in lung surgery.

Purpose of the Study:

  • To systematically evaluate the efficacy and safety of perioperative methylprednisolone (MP) in lung surgery.
  • To quantify the clinical benefits and risks associated with MP administration.
  • To provide evidence-based insights into MP's role in postoperative pain management and complication reduction.

Main Methods:

  • A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted.
  • Searched seven electronic databases for RCTs comparing MP with placebo.
  • Coprimary outcomes included rest and dynamic pain scores, and 24-hour morphine equivalent consumption.

Main Results:

  • Eleven trials with 643 participants were analyzed.
  • MP showed a statistically significant but not clinically meaningful reduction in pain scores and opioid consumption.
  • MP significantly reduced interleukin-6 levels, acute lung injury, and cognitive dysfunction.

Conclusions:

  • Perioperative methylprednisolone provides insignificant relief for acute postoperative pain in lung surgery.
  • MP may play a role in reducing pulmonary and surgical complications.
  • Future research should investigate MP's potential in mitigating these complications.
Keywords:
Lung surgeryMeta-analysisMethylprednisolone (MP)Perioperative multimodal analgesiaSystematic review

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