Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Erasmus-Polyneuropathy Symptom Score for the Screening of Chronic Axonal Polyneuropathy: A Validation Study.

Journal of the peripheral nervous system : JPNS·2026

Same author

Impact of Analytical Decisions on Physical Activity Outcomes in a Cardiovascular Mobile Health Study.

Journal of the American Heart Association·2026

Same author

Bi- and Mono-Allelic RFC1 Expansion in a North American Cohort With Idiopathic Axonal Neuropathy.

Annals of clinical and translational neurology·2026

Same author

Message From the Editors to Our Reviewers.

Neurology·2026

Same author

The Role of Implicit Bias in Shaping Medication Prescribing Practices: A Scoping Review.

Journal of the American College of Clinical Pharmacy : JACCP·2026

Same author

Clinical Diabetic Peripheral Neuropathy: Can It Be Reversed? Arguments for and Against From a NEUROdiab Debate.

Journal of the peripheral nervous system : JPNS·2026

Search research articles

Related Experiment Video

Updated: Aug 25, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Chemotherapy-Induced Peripheral Neuropathy Detection via a Smartphone App: Cross-sectional Pilot Study.

Ciao-Sin Chen¹, Judith Kim¹, Noemi Garg¹

¹Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, United States.

JMIR Mhealth and Uhealth

|October 19, 2022

Summary

Smartphone apps can feasibly assess chemotherapy-induced peripheral neuropathy (CIPN) using functional tests. Objective data from these apps may help monitor CIPN, improving patient care and quality of life.

Keywords:

9-Hole Peg Test balance chemotherapy-induced peripheral neuropathy gait mobile health smartphone

More Related Videos

Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line

Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line

Published on: August 9, 2014

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

Related Experiment Videos

Last Updated: Aug 25, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line

Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line

Published on: August 9, 2014

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

Area of Science:

Oncology
Neurology
Digital Health

Background:

Chemotherapy-induced peripheral neuropathy (CIPN) significantly impacts patients' quality of life and daily activities.
Current CIPN monitoring relies on subjective patient self-reports, lacking objective assessment.
Objective assessment is challenging due to specialized training and equipment requirements.

Purpose of the Study:

To evaluate the feasibility of using a smartphone application for objective functional assessment of CIPN.
To explore the potential of digital tools in monitoring neurotoxicity in cancer patients.

Main Methods:

A pilot study enrolled 26 cancer patients who received neurotoxic chemotherapy.
Participants completed subjective surveys (CIPN20, PRO-CTCAE) and objective functional tests (Gait and Balance, 9-Hole Peg Test) via the NeuroDetect smartphone app.
Data analysis involved partial least squares to identify distinguishing features between CIPN cases and controls.

Main Results:

CIPN cases exhibited significantly shorter step length and distinct gait patterns compared to controls.
Objective functional assessments revealed differences in manual dexterity in dominant hands.
Exploratory analysis indicated associations between functional features and specific symptom subtypes and patient-reported outcomes.

Conclusions:

Smartphone-based functional assessments are feasible for remote CIPN monitoring.
Objective data from apps can potentially identify CIPN manifestations in hands and feet.
Further research is needed to refine functional assessments for clinical CIPN monitoring.