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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Adult Stem Cells01:33

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Collection of Serum- and Feeder-free Mouse Embryonic Stem Cell-conditioned Medium for a Cell-free Approach
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A stem cell aging framework, from mechanisms to interventions.

Beibei Liu1, Jing Qu2, Weiqi Zhang1

  • 1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.

Cell Reports
|October 19, 2022
PubMed
Summary
This summary is machine-generated.

Stem cell aging involves epigenetic changes, protein loss, and systemic factors like inflammation. Understanding these mechanisms can lead to therapies for aging and related diseases.

Keywords:
CP: Stem cell researchchronic inflammationcircadian rhythmepigenetic changesmetabolic disorderprotein homeostasisstem cell agingtissue homeostasis

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Area of Science:

  • Gerontology and Regenerative Medicine
  • Stem Cell Biology
  • Molecular and Cellular Biology

Background:

  • Stem cells are crucial for tissue repair and function.
  • Aging leads to stem cell decline, impacting tissue regeneration.
  • Recent technological advances allow detailed study of stem cell aging mechanisms.

Purpose of the Study:

  • To review aging-related features in somatic stem cells.
  • To explore epigenetic alterations, protein homeostasis loss, and systemic factors in stem cell aging.
  • To discuss potential biomarkers and stem cell-based therapies for healthy aging and age-related diseases.

Main Methods:

  • Literature review and synthesis of current research on stem cell aging.
  • Focus on molecular and cellular mechanisms including epigenetics and proteostasis.
  • Analysis of systemic factors influencing stem cell aging, such as inflammation and metabolic health.

Main Results:

  • Identified common aging phenotypes across various somatic stem cell types.
  • Highlighted the roles of epigenetic drift, impaired protein quality control, chronic inflammation, circadian disruption, and metabolic dysfunction.
  • Summarized biological implications and potential biomarkers of stem cell aging.

Conclusions:

  • Stem cell aging is a multifaceted process influenced by intrinsic and extrinsic factors.
  • Targeting stem cell aging pathways offers therapeutic potential for age-related conditions.
  • Further research into stem cell aging biomarkers and therapies can promote healthy longevity.