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Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
Published on: December 15, 2017
Harnessing bioengineered microbes as a versatile platform for space nutrition.
Briardo Llorente1,2, Thomas C Williams3,4, Hugh D Goold3,4,5
1ARC Center of Excellence in Synthetic Biology, Macquarie University, Sydney, NSW, 2109, Australia. briardo.llorente@mq.edu.au.
Developing bioengineered yeast for space travel offers a sustainable food solution. This microbial platform provides customizable nutrition and sensory profiles, minimizing waste and resource needs for long-duration missions.
Area of Science:
- Synthetic biology
- Astrobiology
- Food science
Background:
- Long-duration space voyages necessitate sustainable and resilient food production systems.
- Current food manufacturing methods are resource-intensive and generate significant waste.
- Maintaining nutritional and sensory quality in confined environments is a major challenge.
Purpose of the Study:
- To explore the potential of bioengineered microorganisms as a flexible food production platform.
- To consolidate nutritional and sensory attributes into a single microbial system.
- To develop a food system with minimal inputs, footprint, and waste for space exploration and Earth-based applications.
Main Methods:
- Engineering a yeast collection for one-carbon metabolism.
- Optimizing yeast for nutritional content, texture, taste, aroma, and color.
- Evaluating the yeast platform's potential for customizable food production.
Main Results:
- A bioengineered yeast collection can be developed to possess diverse sensory and nutritional characteristics.
- This platform offers a method for producing tailored food components.
- The system demonstrates potential for reduced resource consumption and waste generation.
Conclusions:
- Bioengineered yeast presents a viable solution for sustainable food production in space.
- This microbial food production paradigm can enhance self-sufficiency and reduce environmental impact on Earth.
- Further development could revolutionize food manufacturing for both extraterrestrial and terrestrial applications.
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