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Updated: Aug 24, 2025
Surgical Treatment of an Endolymphatic Sac Tumor
Published on: May 26, 2023
Lacrimal sac lymphoma: a case series and literature review
Feng-Xi Meng1,2,3, Han Yue1,2,3, Yi-Qun Yuan1,2,3
1Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200031, China.
Aim:
To study the clinical and pathological characteristics of the lacrimal sac lymphoma, which is rare but it is the major type of non-epithelial malignant tumor in the lacrimal sac region.
Methods:
Sixty-four cases of malignant lacrimal sac tumors in our hospital from 1986 to 2020 were retrospectively reviewed. Eight cases of lacrimal sac lymphoma were carefully reviewed.
Results:
There were five mucosal-associated lymphoid tissue (MALT) lymphomas, one diffused large B-cell lymphoma, one NK/T cell lymphoma, and one mantle cell lymphoma. All eight patients represented symptoms of epiphora with swelling in the lacrimal sac for a certain period of time and showed no signs of systemic involvement at the first time of clinical visits. They had received either chemotherapy or radiotherapy after surgery. Long-term follow-up (from 11 to 220mo) showed that, except one patient with MALT lymphoma died for unknown reasons at 104mo after surgery, the other 7 patients were all alive with no signs of local recurrence, neither in other organs.
Conclusion:
Non-epithelial malignant tumors of the lacrimal sac are rare and lymphoma is the major subtype.
