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Computed Tomography01:10

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
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Minimally Invasive Polarization Sensitive Optical Coherence Tomography (PS-OCT) for assessing Pre-OA, a pilot study

S Martin1,2,3, C Rashidifard1, D Norris4

  • 1Brigham and Women's Hospital, Boston, MA, USA.

Osteoarthritis and Cartilage Open
|October 20, 2022
PubMed
Summary

Polarization sensitive optical coherence tomography (PS-OCT) shows promise in identifying early osteoarthritis (OA) and predicting its progression. Further development of the endocatheter is needed for clinical trials.

Keywords:
CartilageChondroprotectionMRIOCTOpticalOsteoarthritisPolarizationPre-OA

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Area of Science:

  • Biomedical Imaging
  • Orthopedics
  • Medical Technology

Background:

  • Osteoarthritis (OA) progression necessitates chondroprotective strategies.
  • Current imaging lacks resolution for early, reversible pre-OA stages.
  • Polarization-sensitive optical coherence tomography (PS-OCT) shows potential for pre-OA detection.

Purpose of the Study:

  • To assess the feasibility of intraarticular PS-OCT using a flexible endocatheter.
  • To evaluate PS-OCT's ability to identify pre-OA and predict OA progression.
  • To inform the design of future clinical trials for minimally invasive OA detection.

Main Methods:

  • A feasibility study involving 15 patients undergoing arthroscopic partial medial meniscectomy.
  • Intraarticular PS-OCT performed via a flexible endocatheter introduced through a spinal needle.
  • Magnetic resonance imaging (MRI) at baseline and 2.5 years for OA development assessment.

Main Results:

  • Over half of the patients developed OA within 2.65 years.
  • PS-OCT successfully imaged all cartilage surfaces, identifying abnormalities missed by MRI.
  • PS-OCT assessments showed promise in predicting OA progression (p < 0.008), though study power was limited.

Conclusions:

  • Medial meniscectomy patients are suitable for PS-OCT studies predicting OA.
  • Significant endocatheter redesign is required for optimal intraarticular PS-OCT performance.
  • This pilot study provides critical insights for larger clinical trials on minimally invasive pre-OA detection.