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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
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The relationship between intracoronary thrombus burden and atherogenic index in patients with ST-elevation myocardial

N Emlek1, H Duman, M M Ögütveren

  • 1Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey. emleknadir53@gmail.com.

European Review for Medical and Pharmacological Sciences
|October 20, 2022
PubMed

Insights

The atherogenic index (ATI) is a reliable predictor of high coronary thrombus burden in ST-segment elevation myocardial infarction (STEMI) patients. Higher ATI indicates increased risk of adverse cardiovascular outcomes.

Area of Science:

  • Cardiology
  • Biomarkers
  • Interventional Cardiology

Background:

  • Increased coronary thrombus load predicts adverse cardiovascular (CV) outcomes.
  • Identifying predictors of intracoronary thrombus burden is crucial for managing ST-segment elevation myocardial infarction (STEMI).

Purpose of the Study:

  • To evaluate the relationship between the atherogenic index (ATI) and coronary thrombus burden in STEMI patients.

Main Methods:

  • 139 STEMI patients undergoing primary percutaneous coronary intervention were analyzed.
  • Angiographic thrombus burden was classified using the TIMI study group criteria.
  • Patients were divided into high and low thrombus burden groups.

Main Results:

  • The atherogenic index (ATI) was an independent predictor of high thrombus burden (OR: 4.23, p<0.001).
  • Serum creatinine and non-LAD involvement were also independent predictors.
  • ATI's association with thrombus load was independent of HDL and TGL levels.

Conclusions:

  • The atherogenic index (ATI) can serve as a reliable marker for increased coronary thrombus burden.
  • Increased coronary thrombus burden is linked to adverse CV outcomes.
Abstract

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